The study of hormone-like properties of glioxyren

Authors

  • I. I. Shevtsov National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.20.18

Keywords:

glioxyren, derivatives of 2-oxoindoline-3-glyoxyllic acid, diuretic activity, dopamine-renal receptor agonist, antagonist of aldosterone

Abstract

Aim. To study the possible interaction of glioxyrene (a new diuretic substance – a derivative of 2-oxoindoline-3-glyoxyllic acid) with renal receptors of mineralocorticosteroids; to find out the possible role of the dopamine-like effect in the renal effects of glioxyren, as well as study the effectiveness of the simultaneous use of inhibitors of dopamine receptors and glioxyren.
Materials and methods. In the experiment in rats the interaction of glioxyren with peripheral renal receptors of dopamine was studied through the effect of the substance on diuresis under blockade of these receptors with domperidone (a blocker of peripheral receptors of dopamine) in the dose of 50 mg/kg. Diuresis, excretion of sodium and potassium were determined for 2 hours. The effect of glioxyren on the receptors of mineralocorticoids on the background of the partial blockade of these receptors by spironolocton in the oral dose of 20 mg/kg was studied. Water diuresis, excretion of sodium and potassium was studied for 2 hours.
Results and discussion. It has been found that there is the stimulation of water diuresis with glioxyrene as a result of strengthening of the renal blood flow, activation of sodium excretion due to inhibition of sodium reabsorption as a result of the effect on the epithelium of the nephron tubules, stimulation of natriurea and reduction of potassium due to inhibition of aldosterone secretion in the adrenal glands.
Conclusions. Glioxyren has the properties of a dopamine renal receptor agonist as it causes renal dopaminespecific effects associated with the activation of peripheral dopamine receptors. Glioxyren is not an aldosterone renal receptor antagonist.

Author Biography

I. I. Shevtsov, National University of Pharmacy

associate professor of the Department of Pathological Physiology

References

Shimanovskii, N. L., Epinetov, M. A., Melnikov, M. Ia. (2010). Molekuliarnaia i nanofarmakologiia. Moscow : Fizmatlit, 624.

Gracheva, V. V., Karpova, I. V., Iakimovskogo, A. F. (Eds.). (2017). Osnovy fiziologii pochki pod obshchei redaktciei. St-Petersburg : SpetcLit, 153.

Luther, J. M. (2016). Aldosterone in vascular and metabolic dysfunction. Current Opinion in Nephrology and Hypertension, 25 (1), 16–21. https://doi.org/10.1097/mnh.0000000000000189

Orlov, V. D., Lipson, V. V., Ivanov, V. V. (2005). Meditcinskaia khimiia. Kharkov: Folio, 461.

Sergeev, P. V., Shimanovskii, N. L. Petrov, V. N. (1999). Retceptory fiziologicheski aktivnykh veshchestv. Volgograd: Izd–vo “Sem vetrov”, 508.

Berkhin, E. B. (1977). Metody izucheniia vliianiia novykh khimicheskikh soedinenii na funktciiu pochek. Khimiko–farmatcevticheskii zhurnal, 11 (5), 3–11.

Aleskovskii, V. B., Bardin, V. V., Boichinova, E. S., Bulatov, M. I. (1988). Atomno–absorbtcionnyi fotometricheskii spektralnyi analiz i fotometriia plameni. Fiziko-khimicheskie metody analiza: Prakticheskoe rukovodstvo. Leningrad : Khimiia, 138–176.

Tolmacheva, E. A. (Ed.). (2018). Spravochnik Vidal. Lekarstvennye preparaty v Rossii 2018. Vidal Rus, 1240.

Sernov, L. N., Gatcura, V. V. (2000). Elementy eksperimentalnoi farmakologii. Moscow : Meditcina, 308–315, 117–126, 318–320, 236–315.

Downloads

Published

2020-01-27

Issue

No. 1(99) (2020)

Section

Experimental and Clinical Pharmacology

License

Copyright (c) 2020 National University of Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).