Amino acids in cardiology, gastroenterology and neurology

Authors

  • N. A. Gorchakova Bogomolets National Medical University, Ukraine
  • A. V. Zaychenko Bogomolets National Medical University, Ukraine
  • K. Yu. Sorokopud Bogomolets National Medical University, Ukraine

DOI:

https://doi.org/10.24959/nphj.20.19

Keywords:

amino acids, pathogenesis, cardiology, gastroenterology, neurology

Abstract

Aim. To determine the role of amino acids in cardiology, gastroenterology and neurology.

Materials and methods. The material of the article was the literature data on the use of amino acids in cardiology, gastroenterology and neurology, which were processed by methods of generalization and systematization.

Results and discussion. Data on the role of leucine, isoleucine, and valine in the pathogenesis of heart failure and the effect on their metabolism for prophylactic and therapeutic purposes are provided. The antiatherogenic role of glycine and leucine, taurine and arginine in the metabolic syndrome has been highlighted. The neuroprotective and cardioprotective values of L-arginine, and the neurotransmitter value of glutamate have been indicated. The attention is focused on the role of amino acids in the implementation of hepatoprotection.

Conclusions. In the pathogenesis of cardiovascular, gastroenterological, neurological diseases a significant role is given to amino acids. The analysis of the literature data confirms the rationality of the introduction of drugs containing branched-chain amino acids in order to achieve cardioprotective, neuroprotective and hepatoprotective effects.

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Published

2020-01-27

Issue

No. 1(99) (2020)

Section

Experimental and Clinical Pharmacology

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