Creation of combined pessaries with fluconazole and amaranth oil for the treatment of vaginal candidiasis

Authors

DOI:

https://doi.org/10.24959/nphj.20.26

Keywords:

vaginal candidiasis, pessaries, fluconazole, polyethylene oxide bases, amaranth oil

Abstract

Aim. To experimentally substantiate the composition and technology of combined pessaries on a polyethylene oxide base with fluconazole and amaranth oil for the treatment of vaginal candidiasis.

Materials and methods. The study object was samples of pessaries based on polyethylene oxides 400 and 1500 in the ratio of 1:9. These samples were made by the method of pouring. During the work the following research methods were used: organoleptic (appearance, color, odor and homogeneity) pharmacotechnological (determination of homogeneity, decomposition of pessaries and resistance to destruction), physical and chemical (absorption spectrophotometry in the UV spectrum) and biopharmaceutical ones.

Results and discussion. To create pessaries the substance fluconazole possessing antibacterial properties and amaranth oil were used. We decided to take PEO as a suppository base due to the presence of the hyperosmolar action, which was relevant for the use of suppositories in gynecology. In this article, the results of the studies of the pessaries samples with the subsequent substantiation of the composition and their manufacturing technology are presented.

Conclusions. As a result of the studies conducted the composition has been experimentally substantiated, and the rational technology for production of combined pessaries on a polyethylene oxide base with fluconazole and amaranth oil has been developed.

Author Biographies

V. M. Chushenko, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Pharmacy (Ph.D.), associate professor of the Technology of Drugs Department

Yu. V. Levachkova, National University of Pharmacy of the Ministry of Health of Ukraine

Doctor of Pharmacy (Dr. habil.), associate professor of the Technology of Drugs Department

I. V. Herasymova, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Pharmacy (Ph.D.), associate professor of the Technology of Drugs Department

T. P. Osolodchenko, SI “Mechnikov Institute of Microbiology and Immunology” of the National Academy of Medical Sciences of Ukraine

Candidate of Biology (Ph.D.), associate professor

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Published

2020-09-24

Issue

No. 2(100) (2020)

Section

Technology of Medicines

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