Creation of combined pessaries with fluconazole and amaranth oil for the treatment of vaginal candidiasis
Keywords:vaginal candidiasis, pessaries, fluconazole, polyethylene oxide bases, amaranth oil
Aim. To experimentally substantiate the composition and technology of combined pessaries on a polyethylene oxide base with fluconazole and amaranth oil for the treatment of vaginal candidiasis.
Materials and methods. The study object was samples of pessaries based on polyethylene oxides 400 and 1500 in the ratio of 1:9. These samples were made by the method of pouring. During the work the following research methods were used: organoleptic (appearance, color, odor and homogeneity) pharmacotechnological (determination of homogeneity, decomposition of pessaries and resistance to destruction), physical and chemical (absorption spectrophotometry in the UV spectrum) and biopharmaceutical ones.
Results and discussion. To create pessaries the substance fluconazole possessing antibacterial properties and amaranth oil were used. We decided to take PEO as a suppository base due to the presence of the hyperosmolar action, which was relevant for the use of suppositories in gynecology. In this article, the results of the studies of the pessaries samples with the subsequent substantiation of the composition and their manufacturing technology are presented.
Conclusions. As a result of the studies conducted the composition has been experimentally substantiated, and the rational technology for production of combined pessaries on a polyethylene oxide base with fluconazole and amaranth oil has been developed.
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