Salvia officinalis L.: prospects of using the raw material as a source of herbal medicines with the antioxidant and antimicrobic activity




Salvia officinalis, phenolic compounds, terpenoids, pharmacological activity, dosage form, extraction method


There is a worldwide tendecy to increase the use of a specific proportion of medicines based on the medicinal plant raw materials. In this regard, there is a need to clarify the prospect for further research and use of Garden Sage (Salvia officinalis L.) herbal preparations as a plant of official medicine.
Aim. To conduct an informative search of scientific data on the influence of the geographical origin, choice of the solvent and extraction methods on the chemical composition and the biological activity of herbal medicinal products from Garden Sage; to analyze the range of registered medicines from this plant in Ukraine; to determine the promising directions of its phytochemical and pharmacological studies.
Materials and methods. The study objects were the search, analysis and comparison of the current data of scientific literature (2009-2019) concerning the chemical composition, biological activity and use of Garden Sage in medicine. Such databases as Scopus, PubMed, ScienceDirect, ResearchGate, and Google Scholar were used for search and analysis.
Results and discussion. The paper includes the data of scientific literature over the last 10 years regarding the results of phytochemical and harmacological study of the raw material of Garden Sage and herbal products based on it. The major groups of biologically active substances found in Garden Sage include phenolic compounds (flavonoids, hydroxycinnamic acids, tannins) and terpenoids (essential oil, in which mono- and sesquiterpenoids predominate). Di- and triterpene compounds were also present in Garden Sage. The combination of these groups of biological active substances in different herbal medinal products from the Garden Sage provides their high antimicrobial and antioxidant potential. The maximum antioxidant effect was found after extraction using polar solvents due to a high content of polyphenols. The antimicrobial activity was manifested both by terpenoids and phenolic compounds. Currently, the use of opportunities to obtain cell and tissue culture in vitro, as well as modern instrumental methods of analysis, plays a significant role in isolation, identification and determination of the pharmacological activity of new compounds extracted from this plant raw material.
Conclusions. The prospects of future research of the influence of new extraction methods and modern phytochemical methods on the isolation of valuable groups of biological active substances and the pharmacological activity of herbal medicines from Garden Sage have been determined. Leaves, inflorescences and herb of Garden Sage may be considered as a promising source for the development of new herbal medicinal products with the antioxidant and antimicrobial activities.

Author Biographies

N. I. Hudz, Lviv National Medical University by Danylo Halytsky

Candidate of Pharmaceutical Sciences, Associate Professor of the Department of Drug Technology and Biopharmacy

M. I. Shanaida, I. Horbachevsky Ternopil National Medical University Ministry of Health of Ukraine

Candidate of Biological Sciences, Associate Professor of the Department of Pharmacognosy with Medical Botany

R. Ye. Darmogray, Lviv National Medical University by Danylo Halytsky

Candidate of Pharmaceutical Sciences, Associate Professor of the Department of Pharmacognosy and Botany,


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