The effect of moisture regulators on the stability of exemporaneous powders with eufilin

Authors

  • N. F. Orlovetska National University of Pharmacy of the Ministry of Health of Ukraine
  • O. S. Dankevych National University of Pharmacy of the Ministry of Health of Ukraine http://orcid.org/0000-0002-3030-2769
  • R. G. Redkin V. N. Karazin Kharkiv National University http://orcid.org/0000-0003-4412-0496
  • E. I. Shmalii National University of Pharmacy of the Ministry of Health of Ukraine

DOI:

https://doi.org/10.24959/nphj.20.33

Keywords:

powders, difficult extemporaneous prescriptions, extemporaneous formulation, euphilin, aerosol, stability

Abstract

Aim. To study the effect of moisture regulators on the stability of extemporaneous powders with euphilin and substantiate scientifically and experimentally the rational technology of powders according to difficult extemporaneous prescriptions taking into account the physicochemical properties of the ingredients included and the general rules for the preparation of complex powders to increase their shelf-life.

Materials and methods. The extemporaneous formulation of Kharkiv production pharmacies was used; the statistical sample and the purposeful selection of extemporaneous prescriptions were made to identify the study objects. The model samples of powders without and with the addition of aerosol were prepared according to the traditional rules of preparation of complex powders. The organoleptic control in the process of preparation and storage was performed.

Results and discussion. The technology of powders with euphilin has been experimentally substantiated according to difficult extemporaneous prescriptions using two brands of aerosil as a moisture regulator. On the basis of the organoleptic quality control of model powder samples the effect of aerosil as a moisture regulator on the stability of powders during storage has been found.

Conclusions. Based on the technological studies the technology of powders with euphilin has been experimentally substantiated according to difficult extemporaneous prescriptions. The studies conducted allow us to recommend the introduction of the technology of powders developed in the work of production pharmacies as an intra-pharmaceutical preparation.

Author Biographies

N. F. Orlovetska, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Pharmacy (Ph.D), associate professor of the Drug Technology Depatment

O. S. Dankevych, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Pharmacy (Ph.D), associate professor of the Drug Technology Depatment,

R. G. Redkin, V. N. Karazin Kharkiv National University

Candidate of Pharmacy (Ph.D), associate professor of the Department of General Practice of Family Medicine with a course of pharmacology

E. I. Shmalii, National University of Pharmacy of the Ministry of Health of Ukraine

3rd year student

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Published

2020-09-24

Issue

Section

Technology of Medicines