Determination of the particle size of the catiazine substance by laser difraction

Abstract

Aim. To determine the particle size distribution of the new original substance cathiazine by laser diffraction.

Materials and methods. The substance cathiazine was synthesized on the basis of d,l-camphoric acid and 2-aminothiazoline at the Institute of Endocrine Pathology Problems. The sperm-modulating effect of the new compound was proven in experimental animals. Its low toxicity at rather high efficiency was also confirmed. Determination of the particle
size of the powder of the substance cathiazine was performed by laser diffraction. The study was conducted on three laboratory batches. Optical microscopy was used to compare and confirm the results.

Results and discussion. It was found that the average median particle size of the powder of the substance cathiazine was: for batch 1 – 38 μm, for batch 2 – 33 μm, for batch 3 – 53 μm. The maximum size for 80 % of particles of batch 1 was 115 μm, batch 2 – 90 μm, batch 3 – 125 μm. Microphotographs of three batches of the substance cathiazine obtained by optical microscopy were presented. This method also confirmed that the size of the registered particles did not exceed 200 μm. This was in good agreement with the previous studies, in which the recommended average particle size should not exceed 100 μm, and the mass fraction of larger fractions was proposed to be controlled.

Conclusions. The particle size values of the powder substance cathiazine for three laboratory batches have been obtained. It has been found that the particle size and their size distribution in all laboratory batches of the substance cathiazine do not differ significantly. The data obtained can be used to normalize particle sizes in technology when
developing drugs