The study of some pharmacognostic aspects of Ferula persica Wild. (Apiaceae) roots in the flora of Azerbaijan

Authors

DOI:

https://doi.org/10.24959/nphj.24.131

Keywords:

monoterpenes, sulfides, localization

Abstract

Aim. To determine the component composition of the monoterpene fraction of F. persica roots and identify the localization of biologically active substances in the raw material.

Materials and methods. The identification and quantitative analysis were performed using gas chromatography – mass spectrometry. The raw material was collected during the full seed ripening in the vicinity of the village Dzhangi in the Gobustan region of Azerbaijan.

Results and discussion. Using gas chromatography – mass spectrometry, 15 compounds of monoterpenes were identified. The predominant components were heneicosane – 5.10 %; tetradecane – 3.29 %; disulfide, bis(1-methylpropyl) – 2.86 %; heptadecane – 2.50 %; 9,12,15-octadecatrienoic acid 2,3-bis(acetyloxy)propyl ester – 2.39 %; thiophene, 2,3,4-trimethyl- – 2.05 % in the dry raw material. In addition, it was found that resin was localized in large schizogenous receptacles.

Conclusions. The content of monoterpenes in F. persica roots has been determined using gas chromatography – mass spectrometry. The roots contain monoterpenes of heneicosane; tetradecane; disulfide, bis(1-methylpropyl); heptadecane; 9,12,15-octadecatrienoic acid 2,3-bis(acetyloxy)propyl ester. Thiophene and 2,3,4-trimethyl predominate in the raw material.

References

  1. Flora Azerbaidzhana (1955). (6-te vyd.). Baku.
  2. Javidnia, K., Miri, R., Kamalinejad, M., Edraki, N. (2005). Chemical composition ofFerula persica Wild. essential oil from Iran. Flavour and Fragrance Journal, 20 (6), 605-606. doi: 10.1002/ffj.1496.
  3. Iranshahi, M., Amin, G.-R., Jalalizadeh, H., Shafiee, A. (2003). New Germacrane Derivative from Ferula persica. Pharmaceutical Biology, 41 (6), 431-433. doi: 10.1076/phbi.41.6.431.17834.
  4. Karimli, E. G., Khrustalev, V. N., Kurasova, M. N., Akkurt, M., Khalilov, A. N., Bhattarai, A. et al. (2023). Crystal structure and Hirshfeld surface analysis of (5aS,8aR)-3,5a-dimethyl-8-methylidene-2-oxododecahydrooxireno[2′,3′:6,7]naphtho[1,2-b]furan-6-yl (Z)-2-methylbut-2-enoate extracted from Ferula persica. Acta Crystallographica Section E Crystallographic Communications, 79 (5). doi: 10.1107/s205698902300333x.
  5. Karimli, E. G., Khrustalev, V. N., Akkurt, M., Khalilov, A. N., Bhattarai, A., Aleskerova, A. N. et al. (2023). Crystal structure and Hirshfeld surface analysis of 7-[(6-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methoxy]-2H-chromen-2-one. Acta Crystallographica Section E Crystallographic Communications, 79 (9). doi: 10.1107/s2056989023006552.
  6. Kerymly, Э. H., Ybadullaeva, S. Dzh., Aleskerova, A. N. (2023). Badrakemyn y ostol v korniakh Ferula persıca (Apiaceae), proyzrastaiushchei v Azerbaidzhanskoi Respublyke. Rastytelnыe resursы, 5 9(3), 314-320. doi: 10.31857/S0033994623030093.
  7. Iranshahi, M., Amin, G., Shafiee, A. (2004). A New Coumarin fromFerula persica. Pharmaceutical Biology, 42 (6), 440-442. doi: 10.1080/13880200490886102.
  8. Kerimli, E. H., Kerimov, Y. B., Mamedov, A. M. (2023). Constituents of the EtOH Extract of Ferula persica Roots. Chemistry of Natural Compounds, 59, 6. doi: 10.1007/s10600-023-04220-3.
  9. Iranshahi, M., Amin, G.-R., Amini, M., Shafiee, A. (2003). Sulfur containing derivatives from Ferula persica var. latisecta. Phytochemistry, 63 (8), 965-966. doi: 10.1016/s0031-9422(03)00296-6.
  10. Kerimov, Y. B., Abyshev, A. Z., Serkerov, S. V., Isaev, D. I., Bairamov, P. B. (1992). Phenol derivatives from the roots of Ferula persica. Chemistry of Natural Compounds, 28 (5), 506. doi: 10.1007/bf00630666.
  11. Ctetskov, V. V., Luhovskoi, A. Y., Bankovskyi, A. Y., Pakaln, D. N. (1980) Ferula persica flavonoids. Khymyia pryrodnыkh soedynenyi, 3, 415.
  12. Nasri, S., Ghorbani Nohooji, M., Amin, G. R., Sharifi, A., Borbor, M., Shamohamadi, F. et al. (2018). Phytochemical study of methanolic extract of ferula persica willd. inflorescence and its antinociceptive effect in male mice. J. Med. Plants. 17 (68), 136-144.
  13. Serkerov, S. V. (2005). Terpenoydы y fenolproyzvodnыe rastenyi semeistv Asteraceae y Apiaceae. Baku.
  14. Khalylov, R. M., Mamatkhanov, A. U., Kotenko, L. D. (2009). Tekhnolohyia vыdelenyia эstrohennoho preparata ferulen yz kornei feruly tonkorassechennoi. Khymyko-farmatsevtycheskyi zhurnal, 43 (10), 40-43.
  15. Iranshahi, M., Shahverdi, A. R., Mirjani, R., Amin, G., Shafiee, A. (2004). Umbelliprenin from Ferula persica roots inhibits the red pigment production in Serratia marcescens. Zeitschrift für Naturforschung C, 59 (7-8), 506-508.
  16. Iranshahi, M., Askari, M., Sahebkar, A., Hadjipavlou, L. D. (2009). Evaluation of antioxidant, anti-inflammatory and lipoxygenase inhibitory activities of the prenylated coumarin umbelliprenin. DARU Journal of Pharmaceutical Sciences, 17, P. 99-103.
  17. Mirjani, R., Shahverdi, A. R., Iranshahi, M., Amin, G., Shafiee, A. (2005). Identification of Antifungal Compounds from Ferula persica. var. persica. Pharmaceutical biology, 43 (4), 293-295. doi: 10.1080/13880200590951658.
  18. Sattar, Z., Iranshahi, M. (2017). Phytochemistry and pharmacology of Ferula persica Boiss.: A review. Iranian Journal of Basic Medical Sciences, 20 (1), 1. doi: 10.22038/ijms.2017.80855.
  19. Kerymov, Yu., Yslamova, N., Khalylov, D., Ysaev, D. (1999). Praktykum po botanyke. Baku.

Downloads

Published

2024-03-20

Issue

Section

Articles