The methodology for developing a combined gel with the Parmelia sulcata extract for the treatment of wounds and burn injuries
DOI:
https://doi.org/10.24959/nphj.26.206Keywords:
Parmelia sulcata; gel; phytosubstances; burns; wound healing drugs; marketing research.Abstract
Aim. To substantiate the scientific and methodological approach to the development of the composition and technology of a combined gel containing the Parmelia sulcata liquid extract with the anti-inflammatory, antimicrobial, and wound-healing activity for the complex treatment of wounds and burn injuries based on the results of marketing and analytical studies of the pharmaceutical market of Ukraine.
Materials and methods. Information-analytical, bibliosemantic, and marketing research methods were applied. The data sources included the State Register of Medicines of Ukraine, the “Compendium” reference guide, and publications by domestic and foreign researchers. A comparative analysis of medicinal products by dosage forms, active pharmaceutical ingredients, origin, and manufacturers was performed.
Results. It has been found that among semisolid dosage forms for the treatment of wounds and burns there are predominantly ointments and creams, while the proportion of gels is insignificant, particularly among domestic products. Synthetic component-based products predominate 61.99 %, while combined products and plant-based products account for 18.91 %, and 12.60 %, respectively. There are no gels containing phytosubstances for burn and wound management, indicating an unfilled niche in the market. Biologically active components of Parmelia sulcata exhibit antimicrobial, anti-inflammatory, and wound-healing effects, making it a promising active ingredient for a new combined gel.
Conclusions. The expediency of creating a combined gel based on the Parmelia sulcata liquid extract for the local treatment of wounds and burn injuries has been substantiated. The scientific and methodological approach to the development of the composition and technology of a gel with the anti-inflammatory, antimicrobial, and wound-healing activity has been proposed, forming the basis for further experimental studies.
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