Hexafluorosilicates with antibacterial active guanidine containing cations
DOI:
https://doi.org/10.24959/nphj.14.1974Keywords:
hexafluorosilicates, antibacterial active cations, structure, thermochemical transformations, hydrolysisAbstract
The present research has studied the spectral data, thermochemical transformations and hydrolysis of hexafluorosilicates with guanidine containing cations (C22H32Cl2N10)SіF6 (І) and (C21H45N9)(SiF6)1.5 (ІІ) for their potential use as caries-preventive and antibacterial agents. Hexafluorosilicates of the composition I and II were separated as crystalline products of interaction of hexafluorosilicic acid with the methanol solutions of chlorhexidine hydrochloride and polyhexamethylene guanidine hydrochloride. The compounds isolated have been characterized by IR, NMR 19F, mass-spectrometry, thermogravimetric analysis, potentiometry. According to IR spectroscopy data, “onium” hexafluorosilicates I and II have ionic structures. The vibrations of the groups ν(NH), ν(N+H2) in salts I and II appear as strong absorption bands at 3360-3180 cm–1; δ(N+H2) vibrations appear at 1634 and 1637 cm–1. The strong ν(SiF) and δ(SiF2) stretches of SiF6 2– anions are observed in their characteristic regions (at 744, 734 and 482 cm–1, respectively). The singlet character of ν(SiF) and δ(SiF2) vibrations indicates the absence of noticeable distortion of symmetry of SiF6
2– anion with regard to Oh. The NMR 19F spectra of compounds I and II (in DMSO-d6 solutions) have one resonance at –136,70, –135,09 ppm (SiF6 2–); additional resonance at –123,14 ppm, in the case of II it can be related to the octahedral complex anion [SіF5(ДМСО)]–. The results of thermogravimetric analysis are consistent with a multi-stage thermolysis scheme for hexafluorosilicates I and II. The temperatures of thermolysis beginning of complexes I and II are 270 and 100°C, respectively. The compounds I and II studied are characterized by the predicted tendency to hydrolysis in dilute aqueous solutions with formation of orthosilicic acid and fluoride ions, and it allows considering these salts as potential anticaries agents. The study of the biological activity of these compounds is the subject of further investigations.
References
Андриасян Л.Г., Бадалян Г.Р., Брсикян Н.А. и др. // Вестник стоматол. и челюстно-лицевой хирургии. – 2012. – Т. 9, №1. – С. 26-30.
Анисимов В.Ю., Гельмбольдт В.О., Кузьмин В.Е. и др. // Одеський мед. журн. – 2013. – №1. – С. 6-10.
Анисимов В.Ю., Гельмбольдт В.О., Продан О.В. // Одеський мед. журн. – 2013. – №2. – С. 20-23.
Бойко В.В., Бортницкий В.И., Дмитриева Т.В. и др. // Полімерний журн. – 2008. – Т. 30, №3. – С. 251-255.
Климова В.А. Основные микрометоды анализа органических соединений. – М.: Химия, 1975. – 224 с.
Мышляева Л.В., Краснощеков В.В. Аналитическая химия кремния. – М.: Наука, 1972. – 212 с.
Преч Э., Бюльманн Ф., Аффольтер К. Определение строения органических соединений. Таблицы спектральных данных. – М.: Мир; Бином. Лаборатория знаний, 2006. – 438 с.
Andriasyn L.H., Badalyan G.R., Brsikyan N.A. et al. // The New Armenian Med. J. – 2012. – Vol. 6, №4. – P. 52-55.
Eley B.M. // Brit. Dent. J. – 1999. – Vol. 186, №6. – P. 286-296.
Hosoya Y., Otani H., Tadokore K. et al. // J. Oral Sci. – 2013. – Vol. 55, №2. – P. 115-121.
Hosoya Y., Tadokore K., Watanabe E. et al. // J. Oral Sci. – 2012. – Vol. 54, №3. – P. 267-272.
Ishikawa K., Kawasaki A., Suge T. et al. // Dent. Mater. – 2008. – Vol. 24, №2. – P. 192-198.
Kimura T., Shibata S., Suge T. et al. // Am. J. Dent. – 2012. – Vol. 25, №1. – P. 31-34.
Downloads
Published
Issue
Section
License
Copyright (c) 2014 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).