DOI: https://doi.org/10.24959/nphj.14.1983

Determination of the food azo dye carmoisine vs chlorpheniramine maleate ion associate structure

A. S. Materiienko, V. O. Grudko, V. A. Khanin, V. A. Georgiyants

Abstract


Recently different excipients, including colouring agents, are often used to give a marketable appearance and improve the consumer characteristics of drugs. Usually they are applied in the composition of medicines for internal use (tablets, capsules, syrups, troches, lozenges, etc). Synthetic azo dyes – a group of compounds obtained by the coupling reaction of sulfonaftilamines and diazotised sulfoanilines with aromatic or heterocyclic phenols are the most widely used in the pharmaceutical practice. Compounds of this group give bright, easily reproducible colours, they are resistant to the light, oxidants, reducing agents, pH changes and less sensitive to different types of technological impact. Synthetic azo dyes are poorly absorbed from the intestines after intake, but they can form ion associates with salts of organic bases, including with drugs, and it may alter their bioavailability. The aim of our work was to determine the partition coefficient of the ion associate of a synthetic food azo dye carmoisine with the medicinal substance chlorpheniramine maleate in the water-chloroform system and to study the stoichiometric ratio of the components in this ion associate. The partition coefficient in the water-chloroform system has been determined spectrophotometrically. It is 3.44, indicating that the ion associate is more soluble in water than in chloroform. The stoichiometric ratio of carmoisine and chlorpheniramine maleate in the resulting ion associate has been determined by HPLC, and it is 1:2.


Keywords


carmoisine; chlorpheniramine maleate; ion associates; HPLC

Full Text:

PDF

References


Беседнова Н.Н. // Антибиотики и химиотерапия. – 1999. – №1. – С. 31-35.

Вершигора А.Е. Общая иммунология: Учеб. пособие. – К.: Вища шк., 1990. – 736 с.

Воробьев А.А. Эндогенные иммуномодуляторы. – С.Пб.: Гиппократ, 1992. – 255 с.

Державна фармакопея України / Державне підприємство «Науково-експертний центр». – 1-е вид. – Х.: РІРЕГ, 2001. – 556 с.

Косарева О.В. // Известия Самарского научного центра Российской академии наук. – 2009. – Т. 11, №1 (6). – С. 1224-1226.

Тихонов О.І., Ярних Т.Г., Черних В.П. та ін. Теорія та практика виробництва лікарських препаратів прополісу / За ред. О.І.Тихонова. – Х.: Основа, 1998. – 384 с.

Ferrero C., Munoz N., Velasko M.V. et al. // Int. J. Pharm. – 1997. – №147. – P. 11-21.

Gordon M.S., Rudraraju V.S., Dani K., Chowhan Z.T. // Pharm. Sci. – 1993. – №82 (2). – P. 220-226.

Handbook of Pharmaceutical Excipients. 6-th ed. / Ed. by Ainley Wade, Paul J. Weller. American Pharmaceutical Association. – Washington: The Pharmaceutical Press, London, 2006. – 651 p.

Hay W.P., Mueller P.O., Harmon B., Amoroso L. // Vet. Sung. – 2001. – №673 (3). – P. 223-227.

Liu L.S., Berg R.A. // Biomed. Mater. Res. – 2002. – №63 (3). – P. 326-332.

Pharmaceutische Technologie für Studium und Beruf / R. Voigt. Unter Mitarb. von M. Bornschein. 8. Aufl. – Berlin: Wiesbaden: Ullstein Mosby, 1995. – 794 S.

Poongothai J. // Singapore Med. J. – 2009. – №50 (4). – P. 336-347.


GOST Style Citations


1. Грудько В.А., Георгиянц В.А., Материенко А.С. // Вестник КазНМУ. – Алматы. – 2013. – №1 (33). – С. 10-14.

2. Компендиум 2011 – лекарственные препараты / Под ред. В.Н.Коваленко, А.П.Викторова. – К.: МОРИОН, 2011. – 2320 с.

3. Материенко А.С., Грудько В.А., Георгиянц В.А. // Научные ведомости БелГУ. Серия Медицина. Фармация. – 2013. – №25 (168), вып. 24. – С. 232-238.

4. Материенко А.С., Грудько В.А., Георгиянц В.А. // Управление, экономика и обеспечение качества в фармации. – 2014. – №1 (33). – С. 10-14.

5. Смирнов Е.В. Пищевые красители. Справочник. – С.Пб.: Изд-во «Профессия», 2009. – 352 с.

6. British Pharmacopoeia. – London. The Stationary Office. – 2001. – Vol. 1-2. – 3199 p.

7. Combined Compendium of Food Additive Specifications FAO JECFA Monographs 1, Vol. I, Vol. 4 – Analytical methods, test procedures and laboratory solutions used by and referenced in food additive specifications. – Rome, 2006. – 1586 p.

8. European Pharmacopoeia. – 6th ed. – Strasbourg: European Department for the Quality of Medicines, 2008. – 2416 p.

9. Rehorek A., Plum A. // Anal. and Bioanal. Chem. – 2007. – Vol. 388, №8. – P. 1653-1662.

10. Vidotti Е.С., Costa W.F., Oliveira C.C. // Talanta. – 2006. – Vol. 68, №3. – P. 516-521.





Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Abbreviated key title: Vìsn. farm.

ISSN 2415-8844 (Online), ISSN 1562-7241 (Print)