The study of a possible general toxical action of 5,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine derivatives
DOI:
https://doi.org/10.24959/nphj.15.2065Keywords:
acute toxicity, chemical substance 5, 7-dihydro-1H-pyrrolo[2, 3-d]pyrimidineAbstract
It has been experimentally proven that with the intraperitoneal way of introduction of Dezapur the maximum tolerated dose for mice is 2000 mg/kg, the least toxic dose – 1000 mg/kg, the median lethal dose – 3000 mg/kg. When the dose of 3500 mg/kg was introduced to rats one animal died; in the dose of 5000 mg/kg there was 100% death of animals, the median lethal dose was 4500 mg/kg of the animal’s weight. In intragastric introduction the maximum dose of Dezapur for mice was 6000 mg/ kg, for rats it was 11000 mg/kg; by the end of the observation period all animals were alive and alert. According to K.K.Sydorov classification the derivative with the code of KMS-211 (“Dezapur”) has been proven to belong to practically nontoxic substances (the VI class of toxicity).References
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