The study of a possible general toxical action of 5,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine derivatives

Authors

  • O. V. Sevryukov National University of Pharmacy, Ukraine
  • V. A. Volkovoy National University of Pharmacy, Ukraine
  • S. V. Kolisnyk National University of Pharmacy, Ukraine
  • K. M. Sytnik National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.15.2065

Keywords:

acute toxicity, chemical substance 5, 7-dihydro-1H-pyrrolo[2, 3-d]pyrimidine

Abstract

It has been experimentally proven that with the intraperitoneal way of introduction of Dezapur the maximum tolerated dose for mice is 2000 mg/kg, the least toxic dose – 1000 mg/kg, the median lethal dose – 3000 mg/kg. When the dose of 3500 mg/kg was introduced to rats one animal died; in the dose of 5000 mg/kg there was 100% death of animals, the median lethal dose was 4500 mg/kg of the animal’s weight. In intragastric introduction the maximum dose of Dezapur for mice was 6000 mg/ kg, for rats it was 11000 mg/kg; by the end of the observation period all animals were alive and alert. According to K.K.Sydorov classification the derivative with the code of KMS-211 (“Dezapur”) has been proven to belong to practically nontoxic substances (the VI class of toxicity).

Author Biography

S. V. Kolisnyk, National University of Pharmacy

Сергій Вікторович Колісник відповідальний секретар журналу "Вісник фармації", професор кафедри аналітичної хімії НФаУ

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Published

2015-06-11

Issue

Section

Experimental and Clinical Pharmacology