Analysis of oromucosal medicinal products in solid dosage forms for therapeutic dentistry

Authors

  • L. I. Shulga National University of Pharmacy, Ukraine
  • K. A. Chikhladze National University of Pharmacy, Ukraine
  • S. M. Rolik National University of Pharmacy, Ukraine
  • S. O. Povetkin National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2078

Keywords:

dental medicinal products with the local action, solid dosage forms, marketing research, pharmaceutical market

Abstract

In order to determine the necessity of creating dental medicinal products the oromucosal dosage forms of the Ukrainian pharmaceutical market have been analysed. Tablet drugs are increasingly used in the treatment of periodontal diseases. Based on the results of the analysis of 35 drugs it has been found that the share of drugs produced in Ukraine (23%) ranks second after Germany (31%) among manufacturer countries. According to the data of the marketing research 54.3% of solid dosage forms are tablets, 25.7% – lozenges and 20% – pastilles. It has been determined that 34.3% of drugs are two-component products, 25.7% – three-component, 20% are one-component and 20% are multi-component. Distinguishing the concept of active substances it has been shown that 77.1% of drugs contain antiseptics, 14.3% – antibiotics, 20% – essential oils, 17.1% – anesthetics. Natural substances as a component are in 8.6% of medicinal products, e.g. phenolic hydrophobic propolis preparation in “Proalor” (LLC “Pharmaceutical company “Zdorovie”, Ukraine), a thick sage extract in “Shavlia” (Natur Product Europa BV, Netherlands) and a solid chlorophyllipt extract in “Chlorophyllipt” tablets (LLC “Pilot Plant “State Scientific Centre on Medicinal Products”, Ukraine). It has been found that there is dominance of combined drugs and a small share of drugs based on natural substances; therefore, creation of oromucosal herbal medicinal products in a solid dosage form is expedient.

Author Biographies

L. I. Shulga, National University of Pharmacy

Head of the Department of general Pharmacy and Safety of drugs Institute of Pharmacy Professionals Qualification Improvement National University of Pharmacy

K. A. Chikhladze, National University of Pharmacy

Teacher of National University of Pharmacy College

S. M. Rolik, National University of Pharmacy

Assistant professor of the Department of general Pharmacy and Safety of drugs Institute of Pharmacy Professionals Qualification Improvement National University of Pharmacy

S. O. Povetkin, National University of Pharmacy

Assistant of the Department of general Pharmacy and Safety of drugs Institute of Pharmacy Professionals Qualification Improvement National University of Pharmacy

References

АТС-класифікація лікарських засобів [http://www.compendium.com.ua].

Державний реєстр лікарських засобів України [http://www.drlz.kiev.ua].

Шульга Л.І., Безценна Т.С., Пімінов О.Ф. та ін. // Запорожский мед. журн. – 2012. – №5. – С. 110-113.

Павленко О.В., Савичук Н.О., Драгомирецька М.С. та ін. // Інноваційні технології – в стоматологічну практику: матеріали ІІІ (Х) з’їзду асоціації стоматологів України, м. Полтава, 16-18 жовтня 2008 р. – Полтава, «Дивосвіт», 2008. – С. 37-41.

Могилюк В.В. // Провізор. – 2009. – №1-2. – С. 32-35.

Шульга Л.І. // Клінічна фармація, фармакотерапія та медична стандартизація. – 2011. – №3-4. – С. 152-156.

Birudaraj R., Mahalingam R., Li X. et al. // Crit Rev The Drug Carrier Syst. – 2005. – Vol. 22, №3. – P. 295-330.

Al-khattawi A., Mohammed A. // Expert Opin. Drug Deliv. – 2013. – Vol. 10, №5. – P. 651-663.

Jothi V., Vijay K.T., Vasudev B. et al. // Advances in Bioscience and Biotechnol. – 2013. – Vol. 4. – P. 15-18.

Bascones-Martínez A., Eignero Ruiz E. // Advances an Periodoncia (Av Periodontal Implantol.). – 2005. – Vol. 3. – P. 111-118.

Zhang D., Liu C., Zhang J. et al. // J. of Southern Medical University. – 2014. – Vol. 34, №9. – P. 1386-1389.

Encyclopedia of pharmaceutical technology / Ed by J.Swarbrick. – 3-rd ed. – NY: Informa Healthcare USA, Inc., 2007. – 4372 p.

Perioli L., Ambrogi V., Giovagnoli S. et al. // AAPS PharmSciTech. – 2007. – Vol. 8, №3. – P. 54.

Wennström J.L. // J. of Periodontol. – 2014. – Vol. 85, №12. – P. 1639-1641.

Downloads

Published

2016-03-11

Issue

No. 1(85) (2016)

Section

Organization and Economy of Pharmacy

License

Copyright (c) 2016 National University of Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).