The investigation of the drug “Decasan” acute and chronic toxicity
DOI:
https://doi.org/10.24959/nphj.16.2127Keywords:
decamethoxinum, “Decasan”, rats, acute toxicity, chronic toxicityAbstract
The intestinal diseases of bacterial aetiology are characterized by high prevalence and a severe course, especially at a young age, concomitant immunity suppression or chronic diseases of the gastrointestinal system. Therefore, it is expedient to search for the new antimicrobial drugs, and it seems promising to use known antimicrobial agent decamethoxinum for the development of peroral medicinal forms, such as “Decasan” that is 0.02% decamethoxinum solution for peroral use worked out by “Yuria Pharm.” This study aimed to determine the parameters of acute toxicity of decamethoxinum substance and “Decasan,” as well as to study the possible toxic effects of the latter in chronic administration. The experiments on rats have shown that “Decasan” at the maximal allowable dose of 20 ml/kg does not cause lethality in rats. For decamethoxinum substance LD50 equals 586 (484:588) mg/kg in intragastric administration, corresponding to the IV class of low toxic substances (500 mg/kg<LD50<5000 mg/kg). The single intragastric administration of decamethoxinum substance at a dose of 400 mg/kg after 2 days causes moderate reversible changes in the gastrointestinal system, in the thymus and adrenal glands. “Decasan” intragastric administration at doses of 3 ml/kg and 30 ml/kg for a period of 30 days to male and female rats does not causes pathological changes in biochemical parameters of the blood (only the decrease in content of albumins is seen in male rats receiving the drug at both doses) as well as in histological structure of the internal organs and functions of the kidney, heart, and CNS.References
Арзамасцев Е.В., Гуськова Т.А., Березовская И.В. и др. / Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ / Под ред. проф. Р.У. Хабриева. – М.: ОАО «Изд-во «Медицина»», 2005. С. – 47–54.
Волкова О.В., Елецкий Ю.К. Основы гистологии с гистологической техникой. – М. – 1982. – 304 c.
Декасан: инструкция по применению [Електронний ресурс]. – Режим доступу: http://tabletki.ua/Декасан
Деркач Н.Н., Штрыголь С.Ю., Койро О.О., Блажеевский Н.Е. // Обзоры по клин. фармакол. и лекарств. терапии. – 2015. – Т. 15, №1. – С. 45–51.
Камышников В.С. Справочник по клинико-биохимической лабораторной диагностике: В 2 т. – Минск: Беларусь, 2000. – Т. 1. – 495 с., Т. 2. – 463 с.
Коваленко В.М. / Доклінічні дослідження лікарських засобів / За ред.: член-кор. АМН України О. В. Стефанова. – К.: Авіцена, 2001. – С. 74–97.
Кожем’якін Ю.М., Хромов О.С., Філоненко М.А., Сайфетдінова Г.А. Науково-практичні рекомендації з утримання лабораторних тварин та роботи з ними. – К.: Авіцена, 2002. – 156 с.
Палій В.Г.: Автореф. дис. … к. мед. н. – Х., 1999. – 23 с.
Палій Г.К., Ковальчук В.П., Деркач Н.М. та ін. // Укр. хіміотер. журн. –2010.– №1-2.– С. 78–82.
Практическое руководство по антиинфекционной химиотерапии / Под ред. Л.С. Страчунского, Ю.Б. Белоусова, С.Н. Козлова. – М.: Боргес, 2002. – 381 с.
Фомин П.Д., Лисов А.И., Козлов С.Н. и др. // Ліки України. –2006. – №12. – С. 74–75.
Barr W., Smith A. // Am. Fam. Physician. – 2014. – Vol. 89, №3. – P.180–189.
Kosek M., Bern C., Guerrant R.L.// Bull. World Health Organ. – 2003. – Vol. 81, №3. – P. 197–204.
Downloads
Published
Issue
Section
License
Copyright (c) 2016 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
