The investigation of the drug “Decasan” acute and chronic toxicity


  • N. M. Derkach National University of Pharmacy, Ukraine
  • S. Yu. Shtrygol’ National University of Pharmacy, Ukraine
  • Yu. B. Laryanovska National University of Pharmacy, Ukraine
  • S. A. Grashenkova National University of Pharmacy, Ukraine



decamethoxinum, “Decasan”, rats, acute toxicity, chronic toxicity


The intestinal diseases of bacterial aetiology are characterized by high prevalence and a severe course, especially at a young age, concomitant immunity suppression or chronic diseases of the gastrointestinal system. Therefore, it is expedient to search for the new antimicrobial drugs, and it seems promising to use known antimicrobial agent decamethoxinum for the development of peroral medicinal forms, such as “Decasan” that is 0.02% decamethoxinum solution for peroral use worked out by “Yuria Pharm.” This study aimed to determine the parameters of acute toxicity of decamethoxinum substance and “Decasan,” as well as to study the possible toxic effects of the latter in chronic administration. The experiments on rats have shown that “Decasan” at the maximal allowable dose of 20 ml/kg does not cause lethality in rats. For  decamethoxinum substance LD50 equals 586 (484:588) mg/kg in intragastric administration, corresponding to the IV class of low toxic substances (500 mg/kg<LD50<5000 mg/kg). The single intragastric administration of decamethoxinum substance at a dose of 400 mg/kg after 2 days causes moderate reversible changes in the gastrointestinal system, in the thymus and adrenal glands. “Decasan” intragastric administration at doses of 3 ml/kg and 30 ml/kg for a period of 30 days to male and female rats does not causes pathological changes in biochemical parameters of the blood (only the decrease in content of albumins is seen in male rats receiving the drug at both doses) as well as in histological structure of the internal organs and functions of the kidney, heart, and CNS.

Author Biographies

N. M. Derkach, National University of Pharmacy

postgraduate student

S. Yu. Shtrygol’, National University of Pharmacy

Head of the department of pharmacology and drugs toxicology

Yu. B. Laryanovska, National University of Pharmacy

Senior researcher of the Central scientific-research laboratory

S. A. Grashenkova, National University of Pharmacy

Researcher of the Central scientific-research laboratory


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Experimental and Clinical Pharmacology